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FDA is investigating new preliminary data suggesting an increased risk of serious skin reactions from the anti-epileptic drugs phenytoin and fosphenytoin if they are taken by Asian patients who are positive for the human leukocyte antigen allele HLA-B*1502. These reactions include Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). Phenytoin is marketed as Dilantin, Phenytek and generics. Fosphenytoin sodium is marketed as Cerebyx and generics. It is estimated that in parts of China, Taiwan, Thailand, Malaysia, Indonesia and the Philippines, 15 percent or more of the population may carry the HLA-B*-1502 allele. The frequency in South Asia, including India, is somewhat lower, and in Japan and Korea it is under one percent. It was previously established that another anti-epileptic drug, carbamazepine, increases the risk of these skin reactions in Asian patients with the HLA-B*1502 allele. FDA has recommended screening patients of Asian ancestry for this allele before prescribing carbamazepine and not starting the drug unless the expected benefit clearly outweighs the risk. In the case of phenytoin and fosphenytoin, the possible risk is still being studied, and there is not enough information at this point to recommend testing for the allele before starting therapy. However, FDA is recommending that physicians avoid using phenytoin as a substitute for carbamazepine in patients who test positive for the HLA-B*1502 allele. With carbamazepine, over 90 percent …
Question by Soko: Can too much sugar cause skin rash?
Can too much sugar cause skin rash? I know there is skin rash in Asia, tht people call it diatez, similuar to Diabetes. But every time you eat something sugary, your skin gets red spots. When you limit your sugar it usually goes away.
Do you know anything about it? Does it happen to you?
Best answer:
Answer by Bobby Ya too much sugar causes followng
1. Wanting sex all the time i mean 24/7.
2. Pimples.
3. Being Hyper all the time.
4 Skin Rashes.
What do you think? Answer below!
Cases Of Hand, Foot And Mouth Virus Reported At Several Area Daycares
Symptoms include sores in the mouth and a skin rash along with congestion, fever and body aches. It typically runs its course in three to five days, Martindale said. The best defense against the virus is frequent hand washing and avoidance of close … Read more on KWTX